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Image Search Results
Journal: bioRxiv
Article Title: Circuit directionality for motivation: lateral accumbens-pallidum, but not pallidum-accumbens, connections regulate motivational attraction to reward cues
doi: 10.1101/474387
Figure Lengend Snippet: Each coronal section represents a range of three sections relative to Bregma (B, in mm). Expression for each animal is plotted at 90% transparency and then per-animal expression is overlaid. Sections run anterior (top) to posterior (bottom). A) Expression map of AAV-hSyn-DIO-hM4D(Gi)-mCherry in VP following CAV2-Cre injections in NAcLSh (i.e., VP → NAcLSh inhibition animals; red). B) Expression map of AAV-hSyn-DIO-mCherry in VP (i.e., controls; black).
Article Snippet: The inhibition group received 0.6 µl of AAV-hSyn-DIO-hM4D(
Techniques: Expressing, Inhibition
Journal: bioRxiv
Article Title: Brief sleep disruption alters synaptic structures among hippocampal and neocortical somatostatin-expressing interneurons
doi: 10.1101/2024.07.22.604591
Figure Lengend Snippet: Brainbow AAV-transduced SST-CRE mice were sleep-deprived for 6 h via gentle handling ( n = 6), or were allowed to sleep freely in their home cage ( n = 7), starting at lights on. A-B- Control mice slept for more than 60-70% of the first half of the light phase, with an average sleep bout length of approximately 50 min. C – Gentle handling interventions needed to prevent sleep in SD mice (cage taps, cage shakes, and nest disturbances) increased over the course of the 6-h SD experiment. D-F- Representative maximum intensity projection images ( D ) showing Brainbow-labeled SST+ interneurons in each of the examined brain regions, corresponding traced neuronal dendritic arbors ( E ), and detail of inset, highlighting dendritic spines ( F ). Scale bars indicate 100 µm. G- Distribution of spine subtypes for quantified for neurons in each region in freely-sleeping and SD mice.
Article Snippet: At age 3-15 months (Sleep: 7.1 ± 4.9 months; SD: 6.9 ± 4.0 months) each mouse was transduced with a cocktail of CRE recombinase-dependent
Techniques: Gentle, Control, Labeling